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Current Challenges for IDO2 as Target in Cancer Immunotherapy

21 Apr 2021

Abstract excerpt

Immune checkpoint inhibitors have revolutionized the clinical approach of untreatable tumors and brought a breath of fresh air in cancer immunotherapy. However, the therapeutic effects of these drugs only cover a minority of patients and alternative immunotherapeutic targets are required. Metabolism of l-tryptophan (Trp) via the kynurenine pathway represents an important immune checkpoint mechanism that controls...

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PMID: 33968089
DOI: 10.3389/fimmu.2021.679953

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