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Pan-cancer landscape of abnormal ctDNA methylation across human tumors.

Cancer genetics - 1 Nov 2022

Bai Yun, Qu Di, Lu Dan, Li Yiwen, Zhao Ning, Cui Guanghua, Li Xue, Sun Xiaoke, Sun Huaibo, Zhao Lihua, Li Qingyuan, Zhang Qi, Han Tiancheng, Wang Song, Yang Yu

Abstract excerpt

BACKGROUND: The aim of this paper is to explore the correlation between circulating tumor DNA (ctDNA) methylation and mutations and its value in clinical early cancer screening. METHODS: We performed target region methylation sequencing and genome sequencing on plasma samples. Methylation models to distinguish cancer from healthy individuals have been developed using hypermethylated genes in tumors and validated...

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PMID: 36152512
DOI: 10.1016/j.cancergen.2022.09.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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