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Multimodal ctDNA profiling for cancer detection and monitoring in pan-cancer patients with advanced disease enrolled in the SHIVA02 trial

2026-07-27

Abstract excerpt

<h4>Background</h4> Liquid biopsy-based monitoring of circulating tumor DNA (ctDNA) holds promises for real-time assessment of tumor burden and treatment response in precision oncology. However, mutation-based approaches alone show limited sensitivity, particularly in low-shedding tumors. We evaluated whether integrating epigenomic biomarkers — specifically LINE-1 retrotransposon (L1PA) hypomethylation and copy n...

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Literature Corpus work
fdcce293-fdae-5c91-96d4-58043da1d478
DOI
10.64898/2026.07.24.26358660
Open publication

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Multimodal ctDNA profiling for cancer detection and monitoring in pan-cancer patients with advanced disease enrolled in the SHIVA02 trialDOI 10.64898/2026.07.24.26358660
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