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Article

Integrative Genome-wide Association Meta-analysis of Aortic Aneurysm and Dissection Identifies Five Novel Genes.

Genomics, proteomics & bioinformatics - 28 Oct 2025

Du Yifan, Guan Yunlong, Shao Zhonghe, Jiang Minghui, Qu Minghan, Kong Yifan, Wu Hongji, Luo Da, Peng Shu, Li Si, Cao Xi, Chen Jing, Ye Ping, Xia Jiahong, Hao Xingjie

Abstract excerpt

Aortic aneurysm and dissection (AAD) is a multifaceted condition characterized by significant genetic predisposition and a considerable contribution to cardiovascular-related mortality. Previous studies have suggested that AAD subtypes share similar genetic mechanisms; however, these studies investigated the subtypes separately. Here, we performed a large genome-wide association study (GWAS) meta-analysis for AAD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40300110
DOI: 10.1093/gpbjnl/qzaf039
PMCID: PMC12902790

Genes

CRIM1
FRK
HMGA2
PALMD
NT5DC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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