Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection.

doi:10.1038/s41467-022-32772-5

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Article

Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection.

Nature communications - 23 Sept 2022

Khatamzas Elham, Antwerpen Markus H, Rehn Alexandra, Graf Alexander, Hellmuth Johannes Christian, Hollaus Alexandra, Mohr Anne-Wiebe, Gaitzsch Erik, Weiglein Tobias, Georgi Enrico, Scherer Clemens, Stecher Stephanie-Susanne, Gruetzner Stefanie, Blum Helmut, Krebs Stefan, Reischer Anna, Leutbecher Alexandra, Subklewe Marion, Dick Andrea, Zange Sabine, Girl Philipp, Müller Katharina, Weigert Oliver, Hopfner Karl-Peter, Stemmler Hans-Joachim, von Bergwelt-Baildon Michael, Keppler Oliver T, Wölfel Roman, Muenchhoff Maximilian, Moosmann Andreas

Abstract excerpt

Antibodies against the spike protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can drive adaptive evolution in immunocompromised patients with chronic infection. Here we longitudinally analyze SARS-CoV-2 sequences in a B cell-depleted, lymphoma patient with chronic, ultimately fatal infection, and identify three mutations in the spike protein that dampen convalescent plasma-mediated...

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Identifiers

PMID: 36151076
DOI: 10.1038/s41467-022-32772-5
PMCID: PMC9508331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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