Article

COVID-19 Infection Induces Substantial Memory B Cell Maturation to Non-Neutralizing Viral Targets

2021-02-22

Abstract excerpt

Dissecting the evolution of memory B cells (MBCs) against SARS-CoV-2 is critical for understanding antibody recall upon secondary exposure. Here, we utilized single-cell sequencing to profile SARS-CoV-2-reactive B cell subsets in 42 COVID-19 patients. We isolated thousands of B cells in multiple distinct subsets specific to the SARS-CoV-2 spike, endemic coronavirus (HCoV) spikes, nucleoprotein (NP), and open readi...

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Literature Corpus work: 727b85d2-86ea-528a-950d-bc284448d808
DOI: 10.2139/ssrn.3790898

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COVID-19 Infection Induces Substantial Memory B Cell Maturation to Non-Neutralizing Viral TargetsDOI 10.2139/ssrn.3790898Read

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