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Article

Single-stranded DNA library preparation uncovers the origin and diversity of ultrashort cell-free DNA in plasma.

Scientific reports - 14 Jun 2016

Burnham Philip, Kim Min Seong, Agbor-Enoh Sean, Luikart Helen, Valantine Hannah A, Khush Kiran K, De Vlaminck Iwijn

Abstract excerpt

Circulating cell-free DNA (cfDNA) is emerging as a powerful monitoring tool in cancer, pregnancy and organ transplantation. Nucleosomal DNA, the predominant form of plasma cfDNA, can be adapted for sequencing via ligation of double-stranded DNA (dsDNA) adapters. dsDNA library preparations, however, are insensitive to ultrashort, degraded cfDNA. Drawing inspiration from advances in paleogenomics, we have applied a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27297799
DOI: 10.1038/srep27859
PMCID: PMC4906518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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