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Article

Computational and structural investigation of deleterious functional SNPs in breast cancer BRCA2 gene.

Sheng wu gong cheng xue bao = Chinese journal of biotechnology - 1 May 2008

Rajasekaran R, Doss George Priya, Sudandiradoss C, Ramanathan K, Rituraj Purohit, Sethumadhavan Rao

Abstract excerpt

In this work, we have analyzed the genetic variation that can alter the expression and the function in BRCA2 gene using computational methods. Out of the total 534 SNPs, 101 were found to be non synonymous (nsSNPs). Among the 7 SNPs in the untranslated region, 3 SNPs were found in 5' and 4 SNPs were found in 3' un-translated regions (UTR). Of the nsSNPs 20.7% were found to be damaging by both SIFT and PolyPhen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18724707
DOI: 10.1016/s1872-2075(08)60042-4

Genes

BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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