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Article

Intratumoral heterogeneity of c-KIT mutations in a feline splenic mast cell tumor and their functional effects on cell proliferation.

Scientific reports - 22 Sept 2022

Hasegawa Yuki, Shosu Kazuha, Tsuji Kanako, Shimoyama Yumiko, Miyama Takako Shimokawa, Baba Kenji, Okuda Masaru, Itamoto Kazuhito, Igase Masaya, Mizuno Takuya

Abstract excerpt

A cat was presented with mast cell tumors (MCTs) of the skin and spleen. During the initial diagnosis, the exon 8 mutation of c-KIT was detected in the masses from skin and spleen by a commercial laboratory test. Consequently, treatment with toceranib was started. After complete remission, because of recurrence on day 117, the spleen and skin tumors were removed, but the cat eventually died on day 191. The...

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Identifiers

PMID: 36138037
DOI: 10.1038/s41598-022-19089-5
PMCID: PMC9499958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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