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Genetic Changes in Mastocytes and Their Significance in Mast Cell Tumor Prognosis and Treatment

22 Jan 2024

Abstract excerpt

Mast cell tumors are a large group of diseases occurring in dogs, cats, mice, as well as in humans. Systemic mastocytosis (SM) is a disease involving the accumulation of mast cells in organs. KIT gene mutations are very often seen in abnormal mast cells. In SM, high KIT/CD117 expression is observed; however, there are usually no KIT gene mutations present. Mastocytoma (MCT)—a form of cutaneous neoplasm—is common...

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PMID: 38275618
DOI: 10.3390/genes15010137

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