Article
A case report of feline mast cell tumour with intertumoral heterogeneity: Identification of secondary mutations c.998G>C and c.2383G>C in KIT after resistance to toceranib.
Veterinary medicine and science - 1 Sept 2024
Tani Hiroyuki, Hifumi Tatsuro, Ito Keita, Kuramoto Tomohide, Miyoshi Noriaki, Fujiki Makoto, Nakayama Tomohiro
Abstract excerpt
A 12-year-old male domestic cat with multiple subcutaneous mast cell tumours (MCTs) presented with a 2-week history of pruritus and raw/bleeding skin from self-trauma at Kagoshima University Veterinary Teaching Hospital. Polymerase chain reaction (PCR) and histopathological analyses revealed intertumoral heterogeneity among tumour locations based on the mutation status of KIT. In addition, the expression pattern...
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