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Article

Growth-inhibitory effects of four tyrosine kinase inhibitors on neoplastic feline mast cells exhibiting a Kit exon 8 ITD mutation.

Veterinary immunology and immunopathology - 15 Dec 2009

Hadzijusufovic Emir, Peter Barbara, Rebuzzi Laura, Baumgartner Christian, Gleixner Karoline V, Gruze Alexander, Thaiwong Tuddow, Pickl Winfried F, Yuzbasiyan-Gurkan Vilma, Willmann Michael, Valent Peter

Abstract excerpt

Systemic mastocytosis (SM) in felines is a rare neoplasm defined by increased growth and accumulation of immature mast cells (MC) in various organs including the spleen. Although in many cases splenectomy is an effective approach, relapses may occur. In these patients, treatment options are limited. Recent data suggest that various Kit tyrosine kinase inhibitors (TKI) interfere with growth of neoplastic MC in...

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Identifiers

PMID: 19505729
DOI: 10.1016/j.vetimm.2009.05.007
PMCID: PMC6763335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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