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Driving midgut‐specific expression and secretion of a foreign protein in transgenic mosquitoes with AgAper1 regulatory elements

26 Apr 2005

Abstract excerpt

The Anopheles gambiae adult peritrophic matrix protein 1 (AgAper1) regulatory elements were used to drive the expression of phospholipase A2 (PLA2), a protein known to disrupt malaria parasite development in mosquitoes. These AgAper1 regulatory elements were sufficient to promote the accumulation of PLA2 in midgut epithelial cells before a blood meal and its release into the lumen upon blood ingestion. Plasmodium...

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PMID: 15926896
DOI: 10.1111/j.1365-2583.2004.00557.x

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