Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement Strategies

Abstract excerpt

While efforts to control malaria with available tools have stagnated, and arbovirus outbreaks persist around the globe, the advent of CRISPR-based gene editing has provided exciting new opportunities for genetics-based strategies to control these diseases. In one such strategy, called “population replacement”, mosquitoes and other disease vectors are engineered with effector genes that render them unable to...

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