Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii

10 Jul 2023

Abstract excerpt

Proposed genetic approaches for reducing human malaria include population modification, which introduces genes into vector mosquitoes to reduce or prevent parasite transmission. We demonstrate the potential of Cas9/guide RNA (gRNA)–based gene-drive systems linked to dual antiparasite effector genes to spread rapidly through mosquito populations. Two strains have an autonomous gene-drive system coupled to dual...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insect symbiosis and bacterial influences
Share to Invertebrate Immune Response Mechanisms
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37428915
DOI: 10.1073/pnas.2221118120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzziiPMID 37428915Read ↗

Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae.Semantic proximity Read ↗

Population modification strategies for malaria vector control are uniquely resilient to observed levels of gene drive resistance alleles.Semantic proximity Read ↗

The potential of gene drive releases in malaria vector species to reduce the malaria burden in different African environmentsSemantic proximity Read ↗

Performance of low-threshold, population replacement gene drives in cage populations of the yellow fever mosquito, Aedes aegyptiSemantic proximity Read ↗

Mutant allele formation and inheritance during Cas9/guide RNA-mediated gene drive in a population modification mosquito strain for human malaria control.Semantic proximity Read ↗

Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cagesSemantic proximity Read ↗

Double drives and private alleles for localised population genetic control.Semantic proximity Read ↗

Winning the Tug-of-War Between Effector Gene Design and Pathogen Evolution in Vector Population Replacement StrategiesSemantic proximity Read ↗

Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi.Semantic proximity Read ↗

A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppressionSemantic proximity Read ↗

Engineering resilient gene drives for sustainable malaria control by predicting, testing and overcoming target site resistance in Anopheles gambiae.Semantic proximity Read ↗

Cas9/guide RNA-based gene-drive dynamics following introduction and introgression into diverse anopheline mosquito genetic backgroundsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.