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RNA-Based Classification of Homologous Recombination Deficiency in Racially Diverse Patients with Breast Cancer

21 Sept 2022

Abstract excerpt

BACKGROUND: Aberrant expression of DNA repair pathways such as homologous recombination (HR) can lead to DNA repair imbalance, genomic instability, and altered chemotherapy response. DNA repair imbalance may predict prognosis, but variation in DNA repair in diverse cohorts of breast cancer patients is understudied. METHODS: To identify RNA-based patterns of DNA repair expression, we performed unsupervised...

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PMID: 36129803
DOI: 10.1158/1055-9965.epi-22-0590

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