Article

Molecular intrinsic subtypes, genomic and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancers

2022-08-10

Abstract excerpt

<h4>Purpose: </h4> The vast majority of research studies that have described the links between DNA damage repair or homologous recombination deficiency (HRD) score, and tumor biology, have concerned either triple negative breast cancers or cancers with mutation of BRCA 1/2. We hypothesized that ER+/HER2- early breast tumors without BRCA 1/2 mutation could have high HRD score, and aimed to describe their genomic, t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a452a0b4-ec56-588a-8ae6-4a41782c3b98
DOI: 10.21203/rs.3.rs-1776766/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular intrinsic subtypes, genomic and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancersDOI 10.21203/rs.3.rs-1776766/v2Read

Molecular intrinsic subtypes, genomic, and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancersSemantic proximity Read

Integrative Analysis of Homologous Recombination Repair Patterns Unveils Prognostic Signatures and Immunotherapeutic Insights in Breast CancerSemantic proximity Read

Integrative analysis of homologous recombination repair patterns unveils prognostic signatures and immunotherapeutic insights in breast cancer.Semantic proximity Read

Triple-Negative Breast Cancer: Molecular Particularities Still a ChallengeSemantic proximity Read

Examining the prevalence of homologous recombination repair defects in ER+ breast cancers.Semantic proximity Read

Homologous repair deficiency score for identifying breast cancers with defective DNA damage responseSemantic proximity Read

Genomic and transcriptomic profiles associated with response to eribulin and nivolumab combination in HER-2-negative metastatic breast cancer.Semantic proximity Read

Antigen-Presenting B-Cell Signature Predicts Response and Survival in HER2-Positive Breast CancerSemantic proximity Read

Homologous recombination deficiency in primary ER-positive and HER2-negative breast cancerSemantic proximity Read

Impact of Typical Somatic Gene Mutation Characteristics on Homologous Recombination Deficiency in Breast Cancer.Semantic proximity Read

Novel Immune Subtypes Identification of HER2 Positive Breast Cancer Based On Immunogenomic LandscapeSemantic proximity Read

Prognostic Analysis of Patients with Breast Cancer Based on Tumor Mutational Burden, DNA Damage Repair Genes, and Immune InfiltrationSemantic proximity Read