Article

A multiomics signature highlights alterations underlying homologous recombination deficiency in triple-negative breast cancer

2022-01-18

Abstract excerpt

<h4>Background: </h4> Homologous recombination (HR) is a key pathway in DNA double-strand damage repair. HR deficiency (HRD) more commonly occurs in triple-negative breast cancers (TNBCs) than in other breast cancer subtypes. Several clinical trials have demonstrated the value of HRD in stratifying breast cancer patients into distinct response groups to poly ADP ribose polymerase (PARP) inhibitors and chemotherapy...

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Literature Corpus work: 561670b3-982b-5e82-99ab-c1ca1924b4b9
DOI: 10.21203/rs.3.rs-1244930/v1

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