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Aging Impairs Adaptive Unfolded Protein Response and Drives Beta Cell Dedifferentiation in Humans

19 Sept 2022

Abstract excerpt

CONTEXT: Diabetes is an age-related disease; however, the mechanism underlying senescent beta cell failure is still unknown. OBJECTIVE: The present study was designed to investigate whether and how the differentiated state was altered in senescent human beta cells by excluding the effects of impaired glucose tolerance. METHODS: We calculated the percentage of hormone-negative/chromogranin A-positive endocrine...

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PMID: 36125175
DOI: 10.1210/clinem/dgac535

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