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SimBu : bias-aware simulation of bulk RNA-seq data with variable cell-type composition

24 Aug 2022

Abstract excerpt

MOTIVATION: As complex tissues are typically composed of various cell types, deconvolution tools have been developed to computationally infer their cellular composition from bulk RNA sequencing (RNA-seq) data. To comprehensively assess deconvolution performance, gold-standard datasets are indispensable. Gold-standard, experimental techniques like flow cytometry or immunohistochemistry are resource-intensive and...

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PMID: 36124800
DOI: 10.1093/bioinformatics/btac499

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