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Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures

27 Sept 2023

Abstract excerpt

Induced pluripotent stem cell (iPSC) technology enables differentiation of human hepatocytes or hepatocyte-like cells (iPSC-HLCs). Advances in 3D culturing platforms enable the development of more in vivo-like liver models that recapitulate the complex liver architecture and functionality better than traditional 2D monocultures. Moreover, within the liver, non-parenchymal cells (NPCs) are critically involved in...

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PMID: 37830581
DOI: 10.3390/cells12192368

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