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Article

Phenotypic regulation of liver cells in a biofunctionalized three-dimensional hydrogel platform.

Integrative biology : quantitative biosciences from nano to macro - 1 Feb 2016

Kim Myung Hee, Kumar Supriya K, Shirahama Hitomi, Seo Jeongeun, Lee Jae Ho, Cho Nam-Joon

Abstract excerpt

Loss of function is a major challenge for hepatocytes that are cultured on two-dimensional (2D) cell culture platforms. Biofunctionalized three-dimensional (3D) scaffolds produced by microfabrication strategies can overcome these limitations by presenting vital environmental cues, strong mechanical properties, and three-dimensional geometry to enable high-fidelity liver tissue engineering. Herein, we report the...

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PMID: 26792030
DOI: 10.1039/c5ib00269a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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