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Article

Steroidogenic factor-1 and human disease.

Seminars in reproductive medicine - 1 Oct 2012

El-Khairi Ranna, Achermann John C

Abstract excerpt

Steroidogenic factor-1 (SF-1) (Ad4BP, NR5A1) is a nuclear receptor that plays a key role in adrenal and reproductive development and function. Deletion of the gene encoding Sf-1 (Nr5a1) in mice results in severe developmental defects of the adrenal gland and gonad. Consequently, initial work on the potential effects of SF-1 disruption in humans focused on individuals with primary adrenal failure, a 46,XY...

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Identifiers

PMID: 23044873
DOI: 10.1055/s-0032-1324720
PMCID: PMC5159746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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