Article
An Extremes of Phenotype Approach Confirms Significant Genetic Heterogeneity in Patients with Ulcerative Colitis.
Journal of Crohn's & colitis - 18 Mar 2023
Mortlock Sally, Lord Anton, Montgomery Grant, Zakrzewski Martha, Simms Lisa A, Krishnaprasad Krupa, Hanigan Katherine, Doecke James D, Walsh Alissa, Lawrance Ian C, Bampton Peter A, Andrews Jane M, Mahy Gillian, Connor Susan J, Sparrow Miles P, Bell Sally, Florin Timothy H, Begun Jakob, Gearry Richard B, Radford-Smith Graham L
Abstract excerpt
BACKGROUND AND AIMS: Ulcerative colitis [UC] is a major form of inflammatory bowel disease globally. Phenotypic heterogeneity is defined by several variables including age of onset and disease extent. The genetics of disease severity remains poorly understood. To further investigate this, we performed a genome wide association [GWA] study using an extremes of phenotype strategy. METHODS: We conducted GWA analyses...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.