Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of CYP2B6 and CYP2A6 Pharmacogenetic Variation in Sub-Saharan African Populations.

Clinical pharmacology and therapeutics - 1 Mar 2024

Twesigomwe David, Drögemöller Britt I, Wright Galen E B, Adebamowo Clement, Agongo Godfred, Boua Palwendé R, Matshaba Mogomotsi, Paximadis Maria, Ramsay Michèle, Simo Gustave, Simuunza Martin C, Tiemessen Caroline T, Lombard Zané, Hazelhurst Scott

Abstract excerpt

Genetic variation in CYP2B6 and CYP2A6 is known to impact interindividual response to antiretrovirals, nicotine, and bupropion, among other drugs. However, the full catalogue of clinically relevant pharmacogenetic variants in these genes is yet to be established, especially across African populations. This study therefore aimed to characterize the star allele (haplotype) distribution in CYP2B6 and CYP2A6 across...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa South of the Sahara
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2A6

Share to Cytochrome P-450 CYP2B6

Share to Gene Frequency

Share to Genotype

Share to Nicotine

Share to Pharmacogenetics

Source

Identifiers

PMID: 38049200
DOI: 10.1002/cpt.3124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of CYP2B6 and CYP2A6 Pharmacogenetic Variation in Sub-Saharan African Populations.PMID 38049200Read ↗

Characterization of CYP2D6 Pharmacogenetic Variation in Sub-Saharan African Populations.Semantic proximity Read ↗

Characterization of NAT, GST, and CYP2E1 Genetic Variation in Sub-Saharan African Populations: Implications for Treatment of Tuberculosis and Other Diseases.Semantic proximity Read ↗

Characterization of CYP2C19 pharmacogenetic variation in African populations and comparison with other global populations.Semantic proximity Read ↗

The variation landscape of CYP2D6 in a multi-ethnic Asian population.Semantic proximity Read ↗

Comprehensive Allele Genotyping in Critical Pharmacogenes Reduces Residual Clinical Risk in Diverse Populations.Semantic proximity Read ↗

Genetic ancestral patterns in<i>CYP2D6</i>alleles: structural variants, rare variants, and clinical associations in 479,144 UK Biobank genomesSemantic proximity Read ↗

Population pharmacogenomics: an update on ethnogeographic differences and opportunities for precision public healthSemantic proximity Read ↗

The variation landscape of <i>CYP2D6</i> in a multi-ethnic Asian populationSemantic proximity Read ↗

Pharmacogenetic analysis of structural variation in the 1000 genomes project using whole genome sequences.Semantic proximity Read ↗

Characterization of POR haplotype distribution in African populations and comparison with other global populations.Semantic proximity Read ↗

A systematic comparison of pharmacogene star allele calling bioinformatics algorithms: a focus on CYP2D6 genotypingSemantic proximity Read ↗

PharmVar GeneFocus: CYP2B6.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.