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Article

Characterization of CYP2C19 pharmacogenetic variation in African populations and comparison with other global populations.

Pharmacogenomics - 1 Nov 2023

Booyse Ross P, Twesigomwe David, Hazelhurst Scott

Abstract excerpt

Background: CYP2C19 is important in the metabolism of clopidogrel and several antidepressants. This study aimed to characterize the distribution of CYP2C19 star alleles (haplotypes) across diverse African populations compared with global populations. Methods: CYP2C19 star alleles and diplotypes were called from high coverage genomes using the StellarPGx pipeline. Results: CYP2C19*1 (51%), *2 (17%) and *17 (22%)...

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Identifiers

PMID: 37929326
DOI: 10.2217/pgs-2023-0166
PMCID: PMC10694788

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