Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects.

Human genomics - 1 Jan 2009

Matimba Alice, Del-Favero Jurgen, Van Broeckhoven Christine, Masimirembwa Collen

Abstract excerpt

Pharmacogenetics enables personalised therapy based on genetic profiling and is increasingly applied in drug discovery. Medicines are developed and used together with pharmacodiagnostic tools to achieve desired drug efficacy and safety margins. Genetic polymorphism of drug-metabolising enzymes such as cytochrome P450s (CYPs) and N-acetyltransferases (NATs) has been widely studied in Caucasian and Asian...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arylamine N-Acetyltransferase

Share to Black People

Share to Cytochrome P-450 CYP2C19

Share to Cytochrome P-450 CYP2C9

Share to Cytochrome P-450 CYP2D6

Share to Cytochrome P-450 Enzyme System

Source

Open in PubMed Open full text

Identifiers

PMID: 19164093
DOI: 10.1186/1479-7364-3-2-169
PMCID: PMC3525272

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects.PMID 19164093Read ↗

Cytochrome P450 pharmacogenetics in African populations.Semantic proximity Read ↗

Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy.Semantic proximity Read ↗

CYP2C gene polymorphisms in North African populations.Semantic proximity Read ↗

Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major East Asian subpopulations with comparison to Caucasians and Africans.Semantic proximity Read ↗

Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response.Semantic proximity Read ↗

Inter-ethnic differences in genetic polymorphisms of xenobiotic-metabolizing enzymes (CYP1A1, CYP2D6, NAT1 and NAT2) in healthy populations: correlation with the functional in silico prediction.Semantic proximity Read ↗

Pharmacogenomic landscape of a Moroccan cohort: enhancing global diversity and addressing the North African gap.Semantic proximity Read ↗

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome datasetSemantic proximity Read ↗

Genetic ancestral patterns in<i>CYP2D6</i>alleles: structural variants, rare variants, and clinical associations in 479,144 UK Biobank genomesSemantic proximity Read ↗

African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug DevelopmentSemantic proximity Read ↗

CYP3A4*1B and NAT2*14 alleles in a native African population.Semantic proximity Read ↗

Pharmacogenomics in Papua New Guineans: unique profiles and implications for enhancing drug efficacy while improving drug safety.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.