Article
Epi-MEIF: detecting higher order epistatic interactions for complex traits using mixed effect conditional inference forests.
Nucleic acids research - 28 Oct 2022
Saha Saswati, Perrin Laurent, Röder Laurence, Brun Christine, Spinelli Lionel
Abstract excerpt
Understanding the relationship between genetic variations and variations in complex and quantitative phenotypes remains an ongoing challenge. While Genome-wide association studies (GWAS) have become a vital tool for identifying single-locus associations, we lack methods for identifying epistatic interactions. In this article, we propose a novel method for higher-order epistasis detection using mixed effect...
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