Article

Learning epistatic polygenic phenotypes with Boolean interactions

2020-11-25

Abstract excerpt

Detecting epistatic drivers of human phenotypes is a considerable challenge. Traditional approaches use regression to sequentially test multiplicative interaction terms involving pairs of genetic variants. For higher-order interactions and genome-wide large-scale data, this strategy is computationally intractable. Moreover, multiplicative terms used in regression modeling may not capture the form of biological int...

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Literature Corpus work: 31df316e-213b-576f-b261-8966491b724e
DOI: 10.1101/2020.11.24.396846

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