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Article

SerpinB3 drives cancer stem cell survival in glioblastoma

1 Sept 2022

Abstract excerpt

Despite therapeutic interventions for glioblastoma (GBM), cancer stem cells (CSCs) drive recurrence. The precise mechanisms underlying CSC resistance, namely inhibition of cell death, are unclear. We built on previous observations that the high cell surface expression of junctional adhesion molecule-A drives CSC maintenance and identified downstream signaling networks, including the cysteine protease inhibitor...

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Identifiers

PMID: 36103817
DOI: 10.1016/j.celrep.2022.111348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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