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The role of E3 ubiquitin ligases in the development and progression of glioblastoma

11 Jan 2021

Abstract excerpt

Despite recent advances in our understanding of the disease, glioblastoma (GB) continues to have limited treatment options and carries a dismal prognosis for patients. Efforts to stratify this heterogeneous malignancy using molecular classifiers identified frequent alterations in targetable proteins belonging to several pathways including the receptor tyrosine kinase (RTK) and mitogen-activated protein kinase...

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PMID: 33432111
DOI: 10.1038/s41418-020-00696-6

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