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Article

Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation

21 Nov 2014

Abstract excerpt

Different cancer cell compartments often communicate through soluble factors to facilitate tumor growth. Glioma stem cells (GSCs) are a subset of tumor cells that resist standard therapy to contribute to disease progression. How GSCs employ a distinct secretory program to communicate with and nurture each other over the nonstem tumor cell (NSTC) population is not well defined. Here, we show that GSCs...

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PMID: 25464848
DOI: 10.1016/j.celrep.2014.10.055

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