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Cancer stem cells in glioblastoma—molecular signaling and therapeutic targeting

1 Jul 2010

Abstract excerpt

Glioblastomas (GBMs) are highly lethal primary brain tumors. Despite current therapeutic advances in other solid cancers, the treatment of these malignant gliomas remains essentially palliative. GBMs are extremely resistant to conventional radiation and chemotherapies. We and others have demonstrated that a highly tumorigenic subpopulation of cancer cells called GBM stem cells (GSCs) promotes therapeutic...

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PMID: 21203936
DOI: 10.1007/s13238-010-0078-y

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