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Machine learning-based detection of immune-mediated diseases from genome-wide cell-free DNA sequencing datasets

13 Sept 2022

Abstract excerpt

The early detection of tissue and organ damage associated with autoimmune diseases (AID) has been identified as key to improve long-term survival, but non-invasive biomarkers are lacking. Elevated cell-free DNA (cfDNA) levels have been observed in AID and inflammatory bowel disease (IBD), prompting interest to use cfDNA as a potential non-invasive diagnostic and prognostic biomarker. Despite these known...

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PMID: 36100603
DOI: 10.1038/s41525-022-00325-w

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