Article
cfGWAS reveal genetic basis of cell-free DNA end motifs.
Nature communications - 14 Feb 2026
Zhu Huanhuan, Zhang Yan, Li Linxuan, Zeng Shuang, Zhang Xinyi, Lin Ying, Ou Rijing, Wang Lin, Li Xiameizi, Wang Yu, Zeng Jingyu, Lin Yu, Xu Chuang, Zeng Guodan, Li Lingguo, Zhao Rongkang, Jia Yongjian, Luo Fei, Yang Meng, Hu Yuxuan, Xiao Han, Xu Xun, Wang Jian, Zhou Aifen, Zhang Haiqiang, Jin Xin
Abstract excerpt
Cell-free DNA (cfDNA) consists of degraded DNA fragments released into body fluids. Its genetic and pathological information makes it useful for prenatal testing and early tumor detection. However, the mechanisms behind cfDNA biology are largely unknown. In this study, for the first time, we conduct a genome-wide association study (GWAS) to explore the genetic basis of cfDNA end motif frequencies, termed cfGWAS,...
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