Early detection and stratification of colorectal cancer using plasma cell-free DNA fragmentomic profiling

Abstract excerpt

Timely accurate and cost-efficient detection of colorectal cancer (CRC) is of great clinical importance. This study aims to establish prediction models for detecting CRC using plasma cell-free DNA (cfDNA) fragmentomic features. Whole-genome sequencing (WGS) was performed on cfDNA from 620 participants, including healthy individuals, patients with benign colorectal diseases and CRC patients. Using WGS data, three...

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• Cancer Genomics and Diagnostics
• Colorectal Cancer Screening and Detection
• Genetic factors in colorectal cancer