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Article

Mouse tissue harvest-induced hypoxia rapidly alters the in vivo metabolome, between-genotype metabolite level differences, and 13C-tracing enrichments.

Molecular metabolism - 1 Dec 2022

Rauckhorst Adam J, Borcherding Nicholas, Pape Daniel J, Kraus Alora S, Scerbo Diego A, Taylor Eric B

Abstract excerpt

OBJECTIVE: Metabolomics as an approach to solve biological problems is exponentially increasing in use. Thus, this a pivotal time for the adoption of best practices. It is well known that disrupted tissue oxygen supply rapidly alters cellular energy charge. However, the speed and extent to which delayed mouse tissue freezing after dissection alters the broad metabolome is not well described. Furthermore, how...

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Identifiers

PMID: 36100179
DOI: 10.1016/j.molmet.2022.101596
PMCID: PMC9589196

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GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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