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Article

Effect of High-Carbohydrate Diet on Plasma Metabolome in Mice with Mitochondrial Respiratory Chain Complex III Deficiency.

International journal of molecular sciences - 1 Nov 2016

Rajendran Jayasimman, Tomašić Nikica, Kotarsky Heike, Hansson Eva, Velagapudi Vidya, Kallijärvi Jukka, Fellman Vineta

Abstract excerpt

Mitochondrial disorders cause energy failure and metabolic derangements. Metabolome profiling in patients and animal models may identify affected metabolic pathways and reveal new biomarkers of disease progression. Using liver metabolomics we have shown a starvation-like condition in a knock-in (Bcs1lc.232A>G) mouse model of GRACILE syndrome, a neonatal lethal respiratory chain complex III dysfunction with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27809283
DOI: 10.3390/ijms17111824
PMCID: PMC5133825

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