Article
Untargeted plasma metabolite profiling reveals the broad systemic consequences of xanthine oxidoreductase inactivation in mice.
PloS one - 1 Jan 2012
Chen Qiuying, Park Hyeong-Cheon, Goligorsky Michael S, Chander Praveen, Fischer Steven M, Gross Steven S
Abstract excerpt
A major challenge in systems biology is integration of molecular findings for individual enzyme activities into a cohesive high-level understanding of cellular metabolism and physiology/pathophysiology. However, meaningful prediction for how a perturbed enzyme activity will globally impact metabolism in a cell, tissue or intact organisms is precluded by multiple unknowns, including in vivo enzymatic rates,...
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