Article
High glucose alters retinal astrocytes phenotype through increased production of inflammatory cytokines and oxidative stress.
PloS one - 1 Jan 2014
Shin Eui Seok, Huang Qiong, Gurel Zafer, Sorenson Christine M, Sheibani Nader
Abstract excerpt
Astrocytes are macroglial cells that have a crucial role in development of the retinal vasculature and maintenance of the blood-retina-barrier (BRB). Diabetes affects the physiology and function of retinal vascular cells including astrocytes (AC) leading to breakdown of BRB. However, the detailed cellular mechanisms leading to retinal AC dysfunction under high glucose conditions remain unclear. Here we show that...
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