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Article

Cultured Human Foreskin as a Model System for Evaluating Ionizing Radiation-Induced Skin Injury

29 Aug 2022

Abstract excerpt

PURPOSE: Precise molecular and cellular mechanisms of radiation-induced dermatitis are incompletely understood. Histone variant H2A.J is associated with cellular senescence and modulates senescence-associated secretory phenotype (SASP) after DNA-damaging insults, such as ionizing radiation (IR). Using ex vivo irradiated cultured foreskin, H2A.J was analyzed as a biomarker of radiation-induced senescence,...

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PMID: 36077226
DOI: 10.3390/ijms23179830

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