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Genomic characterization of a three-dimensional skin model following exposure to ionizing radiation

21 Aug 2012

Abstract excerpt

This study aimed at characterizing the genomic response to low versus moderate doses of ionizing radiation (LDIR versus MDIR) in a three-dimensional (3D) skin model, which exhibits a closer tissue complexity to human skin than monolayer cell cultures. EpiDermFT skin plugs were exposed to 0, 0.1 and 1 Gy doses of X-rays and harvested at 5 min, 3, 8 and 24 h post-irradiation (post-IR). RNA was interrogated for...

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PMID: 22915785
DOI: 10.1093/jrr/rrs063

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