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Article

Proteomic and phenotypic profiling of replicative-senescent human foreskin fibroblasts under brief heat shock.

Cell stress & chaperones - 1 May 2026

Yue Yang, Chen Hai Feng, Liu Lei

Abstract excerpt

As the largest human organ, the skin experiences lifelong exposure to intrinsic/extrinsic factors that over time diminish its functional capacity and structural integrity. Skin aging involves cellular dysfunction and the loss or fragmentation of extracellular matrix (ECM) fibers, clinically presenting as wrinkles, slackening, and pigmentary abnormalities. The heat shock response (HSR) is a gene regulatory program...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41866108
DOI: 10.1016/j.cstres.2026.100174
PMCID: PMC13049315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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