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Article

Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses.

Human molecular genetics - 1 Nov 2014

Ried Janina S, Shin So-Youn, Krumsiek Jan, Illig Thomas, Theis Fabian J, Spector Tim D, Adamski Jerzy, Wichmann H-Erich, Strauch Konstantin, Soranzo Nicole, Suhre Karsten, Gieger Christian

Abstract excerpt

Availability of standardized metabolite panels and genome-wide single-nucleotide polymorphism data endorse the comprehensive analysis of gene-metabolite association. Currently, many studies use genome-wide association analysis to investigate the genetic effects on single metabolites (mGWAS) separately. Such studies have identified several loci that are associated not only with one but with multiple metabolites,...

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PMID: 24927737
DOI: 10.1093/hmg/ddu301
PMCID: PMC4271073

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