Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection

7 Sept 2022

Abstract excerpt

Cellular necrosis during Mycobacterium tuberculosis (Mtb) infection promotes both immunopathology and bacterial dissemination. Glutathione peroxidase-4 (Gpx4) is an enzyme that plays a critical role in preventing iron-dependent lipid peroxidation-mediated cell death (ferroptosis), a process previously implicated in the necrotic pathology seen in Mtb-infected mice. Here, we document altered GPX4 expression,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helicobacter pylori-related gastroenterology studies
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36069923
DOI: 10.1084/jem.20220504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infectionPMID 36069923Read ↗

BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibilitySemantic proximity Read ↗

Lipid Peroxidation and Type I Interferon Coupling Fuels Pathogenic Macrophage Activation Causing Tuberculosis SusceptibilitySemantic proximity Read ↗

Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infectionSemantic proximity Read ↗

The Role of Ferroptosis and Cuproptosis in Tuberculosis Pathogenesis: Implications for Therapeutic StrategiesSemantic proximity Read ↗

Different modalities of host cell death and their impact on <i>Mycobacterium tuberculosis</i> infectionSemantic proximity Read ↗

Modulation of Ferroptosis During Early <i>Mycobacterium tuberculosis</i> Infection Contributes to Beijing Lineage Strain SA161 VirulenceSemantic proximity Read ↗

A mycobacterial effector promotes ferroptosis-dependent pathogenicity and disseminationSemantic proximity Read ↗

Mycobacterium tuberculosis Induces an Atypical Cell Death Mode to Escape from Infected MacrophagesSemantic proximity Read ↗

Necrosis drives susceptibility to <i>Mycobacterium tuberculosis</i> in Polg <sup>D257A</sup> mutator miceSemantic proximity Read ↗

NINJ1 mediates necrosis of <i>Mycobacterium tuberculosis</i> infected human macrophagesSemantic proximity Read ↗

Macrophage Apoptosis in TuberculosisSemantic proximity Read ↗

Brucella Manipulates Host Cell Ferroptosis to Facilitate Its Intracellular Replication and Egress in RAW264.7 MacrophagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.