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Article

Mycobacterium tuberculosis Induces an Atypical Cell Death Mode to Escape from Infected Macrophages

31 Mar 2011

Abstract excerpt

BACKGROUND: Macrophage cell death following infection with Mycobacterium tuberculosis plays a central role in tuberculosis disease pathogenesis. Certain attenuated strains induce extrinsic apoptosis of infected macrophages but virulent strains of M. tuberculosis suppress this host response. We previously reported that virulent M. tuberculosis induces cell death when bacillary load exceeds ∼20 per macrophage but...

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PMID: 21483832
DOI: 10.1371/journal.pone.0018367

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