Article
Cardiovascular Disease, Aging, and Clonal Hematopoiesis.
Annual review of pathology - 24 Jan 2020
Evans Megan A, Sano Soichi, Walsh Kenneth
Abstract excerpt
Traditional risk factors are incompletely predictive of cardiovascular disease development, a leading cause of death in the elderly. Recent epidemiological studies have shown that human aging is associated with an increased frequency of somatic mutations in the hematopoietic system, which provide a competitive advantage to a mutant cell, thus allowing for its clonal expansion, a phenomenon known as clonal...
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