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Article

Genetics of age-related clonal hematopoiesis and atherosclerotic cardiovascular disease.

Current opinion in cardiology - 1 May 2020

Jung Changhee, Evans Megan A, Walsh Kenneth

Abstract excerpt

PURPOSE OF REVIEW: While advanced age is the major risk factor for the development of atherosclerotic cardiovascular disease (ASCVD), we have a poor understanding of how aging promotes the progression of this disease. Recent evidence suggests that the age-dependent accumulation of somatic mutations in hematopoietic cells may represent a new causal risk factor for ASCVD. RECENT FINDINGS: A hallmark of aging is the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32073406
DOI: 10.1097/HCO.0000000000000726
PMCID: PMC7138732

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