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Article

FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.

The EMBO journal - 15 Jun 2018

Tomida Junya, Takata Kei-Ichi, Bhetawal Sarita, Person Maria D, Chao Hsueh-Ping, Tang Dean G, Wood Richard D

Abstract excerpt

To exploit vulnerabilities of tumors, it is urgent to identify associated defects in genome maintenance. One unsolved problem is the mechanism of regulation of DNA double-strand break repair by REV7 in complex with 53BP1 and RIF1, and its influence on repair pathway choice between homologous recombination and non-homologous end-joining. We searched for REV7-associated factors in human cells and found FAM35A, a...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA, Neoplasm

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Share to Tumor Suppressor p53-Binding Protein 1

Source

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Identifiers

PMID: 29789392
DOI: 10.15252/embj.201899543
PMCID: PMC6003645

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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