Article
ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.
Cell research - 1 Sept 2020
Liu Xiaojing, Liu Tingting, Shang Yafang, Dai Pengfei, Zhang Wubing, Lee Brian J, Huang Min, Yang Dingpeng, Wu Qiu, Liu Liu Daisy, Zheng Xiaoqi, Zhou Bo O, Dong Junchao, Yeap Leng-Siew, Hu Jiazhi, Xiao Tengfei, Zha Shan, Casellas Rafael, Liu X Shirley, Meng Fei-Long
Abstract excerpt
Programmed DNA recombination in mammalian cells occurs predominantly in a directional manner. While random DNA breaks are typically repaired both by deletion and by inversion at approximately equal proportions, V(D)J and class switch recombination (CSR) of immunoglobulin heavy chain gene overwhelmingly delete intervening sequences to yield productive rearrangement. What factors channel chromatin breaks to...
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